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Dnaic1


Official Full Name
dynein axonemal intermediate chain 1
Organism
Mus musculus
Gene ID
68922
Background
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in insulin receptor signaling pathway. Acts upstream of or within determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and heart development. Located in several cellular components, including 9+2 motile cilium; centrosome; and glial cell projection. Is expressed in embryo; spermatozoon; and testis. Used to study Kartagener syndrome; primary ciliary dyskinesia 1; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Dnai1; Dnaic1; b2b1526Clo; 1110066F04Rik

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