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DESMOCOLLIN-2


Official Full Name
desmocollin 2
Organism
Homo sapiens
Gene ID
1824
Background
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Synonyms
DSC2; DG2; DSC3; CDHF2; ARVD11; DGII/III

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CDCL183913 Human Desmocollin-2 ORF clone(NM_024422.3) Inquiry
CDCL183914 Mouse Desmocollin-2 ORF clone(NM_007882.3) Inquiry
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