Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC004119 | Panoply™ Human DDHD1 Knockdown Stable Cell Line | Inquiry |
| CSC-SC004119 | Panoply™ Human DDHD1 Over-expressing Stable Cell Line | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD04673Z | Human DDHD1 adenoviral particles | Inquiry |
| LV10453L | human DDHD1 (NM_001160148) lentivirus particles | Inquiry |
| LV10454L | human DDHD1 (NM_030637) lentivirus particles | Inquiry |
| LV10455L | human DDHD1 (NM_001160147) lentivirus particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHG225657 | shRNA set against Mouse Ddhd1(NM_001039106.2) | Inquiry |
| SHW009216 | shRNA set against Danio rerio DDHD1B (NM_001030246) | Inquiry |
| SHG225793 | shRNA set against Mouse Ddhd1(NM_001042719.1) | Inquiry |
| SHG225811 | shRNA set against Mouse Ddhd1(NM_176845.4) | Inquiry |
| SHG225847 | shRNA set against Rat Ddhd1(NM_001033066.1) | Inquiry |
| SHH275605 | shRNA set against Human DDHD1 (NM_030637.2) | Inquiry |
| SHH275609 | shRNA set against Mouse DDHD1 (NM_176845.4) | Inquiry |
| SHH275613 | shRNA set against Rat DDHD1 (NM_001033066.1) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| CDFG018291 | Mouse Ddhd1 cDNA Clone(NM_001039106.2) | Inquiry |
| MiUTR1M-03736 | DDHD1 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-03735 | DDHD1 miRNA 3'UTR clone | Inquiry |
| CDFR004212 | Rat Ddhd1 cDNA Clone(NM_001033066.1) | Inquiry |
| CDFL003492 | Mouse Ddhd1 cDNA Clone(NM_176845.4) | Inquiry |
| CDFH004873 | Human DDHD1 cDNA Clone(NM_001160148.1) | Inquiry |
| CDFH004872 | Human DDHD1 cDNA Clone(NM_001160147.1) | Inquiry |
| CDFG018523 | Mouse Ddhd1 cDNA Clone(NM_001042719.1) | Inquiry |
| MiUTR1M-03737 | DDHD1 miRNA 3'UTR clone | Inquiry |
| MiUTR1R-01402 | DDHD1 miRNA 3'UTR clone | Inquiry |
| CDCR054198 | Mouse Ddhd1 ORF clone (NM_001042719.1) | Inquiry |
| CDCR054196 | Mouse Ddhd1 ORF clone (NM_001039106.2) | Inquiry |
| CDCR054194 | Mouse Ddhd1 ORF clone (NM_176845.4) | Inquiry |
| CDCR054190 | Human DDHD1 ORF clone (NM_030637.2) | Inquiry |
| CDCR054188 | Human DDHD1 ORF clone (NM_001160148.1) | Inquiry |
| CDCR054186 | Human DDHD1 ORF clone (NM_001160147.1) | Inquiry |
| CDCB185257 | Rabbit DDHD1 ORF clone (XM_002718252.2) | Inquiry |
| CDCR371239 | Rat Ddhd1 ORF Clone(NM_001033066.1) | Inquiry |
| CDCB170691 | Danio rerio DDHD1B ORF Clone (NM_001030246) | Inquiry |
DDHD structural domain-containing proteins belong to the intracellular phospholipase A1 (iPLA1) family and are predicted to be involved in phospholipid metabolism, lipid trafficking, membrane turnover, and signaling. Deletion of cardiolipin (CL), phosphatidylethanolamine and phosphatidylglycerol remodeling leads to Bart's syndrome and mitochondrial dysfunction. The DDHD1 gene, also known as DDHD domain-containing protein 1, is a recently discovered gene that has garnered significant attention in the scientific community due to its potential involvement in various physiological and pathological processes. The DDHD1 gene is a member of the DDHD (Disorder of Alanine Metabolism, D-Alanine-D-Alanine Ligase, Histidine Triad Nucleotide Binding Protein 1) domain family, which is characterized by a unique domain structure that binds to histidine triad motifs.
The DDHD structural domain, originally found in the central portion of the Nir/rdgB (N-terminal structural domain interaction receptor/Drosophila retinal degeneration B) protein, is a 180 amino acid-long stretch of structural domain. The domain has four conserved amino acid residues (DDHD), from which the DDHD domain is named. The domain is also present in the C-terminal region of phosphatidic acid (PA) 3-precursor phospholipase A1 (PA-PLA 1). The DDHD structural domain is predicted to be involved in phospholipid metabolism, lipid trafficking, membrane turnover, and signaling (1). PA-PLA 1/DDHD1, KIAA0725p/DDHD2, and p125/Sec23ip are three mammalian iPLA 1 family members. iPLA 1 family proteins are also found in yeast, nematodes and plants.
Fig1. Gene structure of Ddhd1
There are several reasons why it is important to understand the endogenous metabolic function of DDHD1. To begin with, deleterious mutations in human DDHD1 cause a rare neurological disorder called hereditary spastic paraplegia (HSP) subtype 28 (SPG28).Symptoms of SPG28 include spastic gait, hyperreflexia and mild penetrating peripheral neuropathy, cerebellar eye movements, and urinary incontinence. Other neurologic disorders associated with the mutation include juvenile amyotrophic lateral sclerosis and cerebral iron accumulating neurodegeneration. Therefore, understanding the lipid pathways regulated by DDHD1 in the central nervous system (CNS) may help to provide insight into the mechanistic basis of SPG28 and point the way to future therapeutic strategies for the disease. DDHD1 belongs to a small clade of sequence-associated serine hydrolases known as DDHD proteins, which also includes DDHD2 and SEC23IP. of note. loss-of-function mutations in DDHD2 result in a different form of HSP, SPG54, which manifests as limb spasticity/weakness and intellectual disability.
Apoptosis is a process of programmed cell death that is essential for maintaining tissue homeostasis and eliminating damaged or unwanted cells. Dysregulation of apoptosis has been implicated in various pathological conditions, including cancer, inflammation, and neurodegenerative diseases. Recent studies have suggested that DDHD1 may play a role in regulating apoptosis. For instance, overexpression of DDHD1 has been reported to promote apoptosis in various cell lines, whereas silencing of DDHD1 expression has been shown to inhibit apoptosis.
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