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DUSP4


Official Full Name
dual specificity phosphatase 4
Organism
Homo sapiens
Gene ID
1846
Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
Synonyms
TYP; HVH2; MKP2; MKP-2

Cat.No. Product Name Price
AD05163Z Human DUSP4 adenoviral particles Inquiry
Cat.No. Product Name Price
SHW017274 shRNA set against Danio rerio DUSP4 (NM_201171) Inquiry
SHH019343 shRNA set against Mouse Dusp4(NM_176933.4) Inquiry
SHH019351 shRNA set against Rat Dusp4(NM_022199.1) Inquiry
SHH281873 shRNA set against Human DUSP4 (NM_057158.3) Inquiry
SHH281877 shRNA set against Mouse DUSP4 (NM_176933.4) Inquiry
SHH281881 shRNA set against Rat DUSP4 (NM_022199.1) Inquiry
SHW005344 shRNA set against Chicken DUSP4 (NM_204838) Inquiry
Cat.No. Product Name Price
CDCR273394 Mouse Dusp4 ORF Clone(NM_176933.4) Inquiry
CDFR011886 Rat Dusp4 cDNA Clone(NM_022199.1) Inquiry
MiUTR1M-04067 DUSP4 miRNA 3'UTR clone Inquiry
MiUTR1R-01613 DUSP4 miRNA 3'UTR clone Inquiry
MiUTR3H-05287 DUSP4 miRNA 3'UTR clone Inquiry
MiUTR3H-05288 DUSP4 miRNA 3'UTR clone Inquiry
CDCB166819 Chicken DUSP4 ORF Clone (NM_204838) Inquiry
CDCB178749 Danio rerio DUSP4 ORF Clone (NM_201171) Inquiry
CDCB186950 Rabbit DUSP4 ORF clone (XM_002720829.2) Inquiry
CDCR378889 Rat Dusp4 ORF Clone(NM_022199.1) Inquiry
CDCS410254 Human DUSP4 ORF Clone (BC002671) Inquiry
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