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DUSP3


Official Full Name
dual specificity phosphatase 3
Organism
Homo sapiens
Gene ID
1845
Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
Synonyms
VHR

Cat.No. Product Name Price
SHH281861 shRNA set against Human DUSP3 (NM_004090.3) Inquiry
SHH281865 shRNA set against Mouse DUSP3 (NM_028207.3) Inquiry
Cat.No. Product Name Price
MiUTR1H-03040 DUSP3 miRNA 3'UTR clone Inquiry
CDCB189293 Rabbit DUSP3 ORF clone (XM_008271557.1) Inquiry
CDCH386071 Rat DUSP3 ORF clone(NM_001173376.1) Inquiry
CDCR261165 Mouse Dusp3 ORF Clone(NM_028207.3) Inquiry
CDCS411600 Human DUSP3 ORF Clone (BC035701) Inquiry
CDCS411601 Human DUSP3 ORF Clone (BC002682) Inquiry
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