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DUOXA1


Official Full Name
dual oxidase maturation factor 1
Organism
Homo sapiens
Gene ID
90527
Background
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Synonyms
NIP; mol; NUMBIP

Cat.No. Product Name Price
SHH018137 shRNA set against Human DUOXA1(NM_144565.2) Inquiry
SHH018155 shRNA set against Mouse Duoxa1(NM_145395.2) Inquiry
SHH281581 shRNA set against Human DUOXA1 (NM_144565.2) Inquiry
SHH281585 shRNA set against Mouse DUOXA1 (NM_145395.2) Inquiry
SHH281589 shRNA set against Rat DUOXA1 (NM_001107767.1) Inquiry
Cat.No. Product Name Price
CDCR317487 Human DUOXA1 ORF Clone(NM_144565.2) Inquiry
CDCS416875 Human DUOXA1 ORF Clone (BC029819) Inquiry
CDFG008512 Human DUOXA1 cDNA Clone(NM_144565.2) Inquiry
CDFR007302 Rat Duoxa1 cDNA Clone(NM_001107767.1) Inquiry
MiUTR1H-03024 DUOXA1 miRNA 3'UTR clone Inquiry
MiUTR1M-04048 DUOXA1 miRNA 3'UTR clone Inquiry
CDCB184698 Rabbit DUOXA1 ORF clone (XM_008269069.1) Inquiry
CDCR267164 Mouse Duoxa1 ORF Clone(NM_145395.2) Inquiry
CDCR374313 Rat Duoxa1 ORF Clone(NM_001107767.1) Inquiry
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