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dnmt5


Official Full Name
DNA (cytosine-5-)-methyltransferase beta, duplicate b.3
Organism
Danio rerio
Gene ID
323723
Background
Predicted to enable DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Predicted to be active in nucleus. Is expressed in several structures, including brain; digestive system; head; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta) and DNMT3L (DNA methyltransferase 3 like). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
dnmt5; dnmt3-2; wu:fc08a10; zgc:136325

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