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DNASE1


Official Full Name
deoxyribonuclease 1
Organism
Homo sapiens
Gene ID
1773
Background
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Synonyms
DNL1; DRNI

Cat.No. Product Name Price
SHH279789 shRNA set against Mouse DNASE1 (NM_010061.5) Inquiry
SHH011441 shRNA set against Human DNASE1(NM_005223.3) Inquiry
SHH011449 shRNA set against Mouse Dnase1(NM_010061.5) Inquiry
SHH011477 shRNA set against Rat Dnase1(NM_013097.2) Inquiry
SHH279785 shRNA set against Human DNASE1 (NM_005223.3) Inquiry
SHH279793 shRNA set against Rat DNASE1 (NM_013097.2) Inquiry
SHW006040 shRNA set against Chicken DNASE1 (NM_206957) Inquiry
SHW006667 shRNA set against Danio rerio DNASE1 (NM_001002674) Inquiry
Cat.No. Product Name Price
CDFH005296 Human DNASE1 cDNA Clone(NM_005223.3) Inquiry
CDFH005297 Human DNASE1 cDNA Clone(NM_005223.3) Inquiry
CDFR010898 Rat Dnase1 cDNA Clone(NM_013097.2) Inquiry
MiUTR1H-02928 DNASE1 miRNA 3'UTR clone Inquiry
MiUTR1M-03935 DNASE1 miRNA 3'UTR clone Inquiry
MiUTR1R-01540 DNASE1 miRNA 3'UTR clone Inquiry
CDCB159692 Human DNASE1 ORF clone (BC029437) Inquiry
CDCB167515 Chicken DNASE1 ORF Clone (NM_206957) Inquiry
CDCB168142 Danio rerio DNASE1 ORF Clone (NM_001002674) Inquiry
CDCB180703 Rabbit DNASE1 ORF clone (NM_001082740.1) Inquiry
CDCR056616 Human DNASE1 ORF clone (NM_005223.3) Inquiry
CDCR377975 Rat Dnase1 ORF Clone(NM_013097.2) Inquiry
CDCS412152 Human DNASE1 ORF Clone (BC029437) Inquiry
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