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DIO1


Official Full Name
iodothyronine deiodinase 1
Organism
Homo sapiens
Gene ID
1733
Background
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2018]
Synonyms
5DI; THMA2; TXDI1

Cat.No. Product Name Price
SHH005375 shRNA set against Mouse Dido1(NM_011805.2) Inquiry
SHH005357 shRNA set against Mouse Dido1(NM_175551.3) Inquiry
SHW002644 shRNA set against Chicken DIO1 (NM_001097614) Inquiry
SHH278117 shRNA set against Rat DIO1 (NM_021653.3) Inquiry
SHH278113 shRNA set against Mouse DIO1 (NM_007860.3) Inquiry
SHH278109 shRNA set against Human DIO1 (NM_000792.5) Inquiry
SHH278069 shRNA set against Mouse DIDO1 (NM_175551.3) Inquiry
SHH278065 shRNA set against Human DIDO1 (NM_022105.4) Inquiry
SHH005527 shRNA set against Human DIO1(NM_213593.3) Inquiry
SHH005509 shRNA set against Human DIO1(NM_001039716.1) Inquiry
SHH005491 shRNA set against Human DIO1(NM_001039715.1) Inquiry
SHH005473 shRNA set against Human DIO1(NM_000792.5) Inquiry
SHH005455 shRNA set against Mouse Dio1(NM_007860.3) Inquiry
SHH005453 shRNA set against Rat Dio1(NM_021653.3) Inquiry
SHH005447 shRNA set against Human DIO1(NM_213593.3) Inquiry
SHH005393 shRNA set against Mouse Dido1(NM_177852.3) Inquiry
SHW007564 shRNA set against Danio rerio DIO1 (NM_001007283) Inquiry
SHW010801 shRNA set against Danio rerio DIDO1 (NM_001079955) Inquiry
Cat.No. Product Name Price
MiUTR3H-06589 DIDO1 miRNA 3'UTR clone Inquiry
CDFH005080 Human DIO1 cDNA Clone(NM_001039715.1) Inquiry
MiUTR3H-06588 DIDO1 miRNA 3'UTR clone Inquiry
CDFL003634 Mouse Dido1 cDNA Clone(NM_011805.2) Inquiry
CDFL003635 Mouse Dido1 cDNA Clone(NM_175551.3) Inquiry
CDCR378753 Rat Dio1 ORF Clone(NM_021653.3) Inquiry
CDFR011706 Rat Dio1 cDNA Clone(NM_021653.3) Inquiry
CDCR337688 Human DIO1 ORF Clone(NM_000792.5) Inquiry
MiUTR1H-02827 DIO1 miRNA 3'UTR clone Inquiry
CDCR315255 Human DIDO1 ORF Clone(NM_080796.3) Inquiry
MiUTR1H-02828 DIO1 miRNA 3'UTR clone Inquiry
CDCR055594 Mouse Dio1 ORF clone (NM_007860.3) Inquiry
MiUTR1H-02829 DIO1 miRNA 3'UTR clone Inquiry
MiUTR1H-02830 DIO1 miRNA 3'UTR clone Inquiry
MiUTR1M-03863 DIDO1 miRNA 3'UTR clone Inquiry
MiUTR1M-03864 DIDO1 miRNA 3'UTR clone Inquiry
MiUTR1M-03865 DIDO1 miRNA 3'UTR clone Inquiry
MiUTR1M-03866 DIO1 miRNA 3'UTR clone Inquiry
MiUTR1R-01494 DIO1 miRNA 3'UTR clone Inquiry
MiUTR3H-06587 DIDO1 miRNA 3'UTR clone Inquiry
CDFG022168 Mouse Dio1 cDNA Clone(BC019786) Inquiry
CDFH005079 Human DIO1 cDNA Clone(NM_001039716.1) Inquiry
CDCS409260 Human DIDO1 ORF Clone (BC000770) Inquiry
CDCS409259 Human DIDO1 ORF Clone (BC004237) Inquiry
CDCS405906 Human DIO1 ORF Clone (BC107170) Inquiry
CDCR343859 Human DIO1 ORF Clone(NM_001039716.1) Inquiry
CDCR315257 Human DIDO1 ORF Clone(NM_080797.3) Inquiry
CDCR273154 Mouse Dido1 ORF Clone(NM_175551.3) Inquiry
CDCR055590 Human DIO1 ORF clone (NM_213593.3) Inquiry
CDCR055588 Human DIO1 ORF clone (NM_001039715.1) Inquiry
CDCR055574 Mouse Dido1 ORF clone (NM_177852.3) Inquiry
CDCR055572 Mouse Dido1 ORF clone (NM_011805.2) Inquiry
CDCB181044 Rabbit DIO1 ORF clone (NM_001099958.1) Inquiry
CDCB172276 Danio rerio DIDO1 ORF Clone (NM_001079955) Inquiry
CDCB169039 Danio rerio DIO1 ORF Clone (NM_001007283) Inquiry
CDCB164119 Chicken DIO1 ORF Clone (NM_001097614) Inquiry
CDCS409261 Human DIDO1 ORF Clone (BC012757) Inquiry
CDCB157829 Human DIO1 ORF clone (BC107170) Inquiry
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