Pages
Products

PREX2


Official Full Name
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
Organism
Homo sapiens
Gene ID
80243
Background
The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
Synonyms
DEP.2; DEPDC2; P-REX2; PPP1R129

Cat.No. Product Name Price
SHH382456 shRNA set against Human PREX2 (NM_025170.4) Inquiry
SHH382461 shRNA set against Mouse PREX2 (NM_001033636.4) Inquiry
SHH382464 shRNA set against Rat PREX2 (NM_001107899.1) Inquiry
Cat.No. Product Name Price
CDFG004736 Human PREX2 cDNA Clone(NM_024870.2) Inquiry
CDFG004960 Human PREX2 cDNA Clone(NM_025170.4) Inquiry
CDFG017916 Mouse Prex2 cDNA Clone(NM_001033636.4) Inquiry
CDFL010753 Mouse Prex2 cDNA Clone(NM_029525.1) Inquiry
CDFR007545 Rat Prex2 cDNA Clone(NM_001107899.1) Inquiry
MiUTR1H-02778 PREX2 miRNA 3'UTR clone Inquiry
MiUTR1H-02779 PREX2 miRNA 3'UTR clone Inquiry
CDCB189797 Rabbit PREX2 ORF clone (XM_002710460.2) Inquiry
CDCH067606 human PREX2 ORF clone (NM_024870.2) Inquiry
CDCH067608 human PREX2 ORF clone (NM_025170.4) Inquiry
CDCH067610 Mouse Prex2 ORF clone (NM_029525.1) Inquiry
CDCH067612 Mouse Prex2 ORF clone (NM_001033636.4) Inquiry
CDCR374568 Rat Prex2 ORF Clone(NM_001107899.1) Inquiry
Quick Inquiry