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D2Ertd750e

Official Full Name
kinetochore-localized astrin/SPAG5 binding
Organism
Mus musculus
GeneID
51944
Background
Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to be located in microtubule organizing center; plasma membrane; and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Is expressed in cerebral cortex ventricular layer. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
SKAP; C15orf23; Traf4af1; D2Ertd750e; 1700025D04Rik;

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