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CST3


Official Full Name
cystatin C
Organism
Homo sapiens
Gene ID
1471
Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]
Synonyms
ARMD11; HEL-S-2

Cat.No. Product Name Price
SHW005992 shRNA set against Chicken CST3 (NM_205500) Inquiry
SHG204751 shRNA set against Human CST3(NM_000099.2) Inquiry
SHG204811 shRNA set against Rat Cst3(NM_012837.1) Inquiry
SHG204829 shRNA set against Mouse Cst3(NM_009976.3) Inquiry
SHH270741 shRNA set against Human CST3 (NM_000099.2) Inquiry
SHH270745 shRNA set against Mouse CST3 (NM_009976.3) Inquiry
SHH270749 shRNA set against Rat CST3 (NM_012837.1) Inquiry
SHW009252 shRNA set against Danio rerio CST3 (NM_001031673) Inquiry
Cat.No. Product Name Price
CDFH004380 Human CST3 cDNA Clone(NM_000099.2) Inquiry
CDFR010693 Rat Cst3 cDNA Clone(NM_012837.1) Inquiry
MiUTR1H-02493 CST3 miRNA 3'UTR clone Inquiry
MiUTR1M-03406 CST3 miRNA 3'UTR clone Inquiry
MiUTR1R-01240 CST3 miRNA 3'UTR clone Inquiry
CDCB167467 Chicken CST3 ORF Clone (NM_205500) Inquiry
CDCB170727 Danio rerio CST3 ORF Clone (NM_001031673) Inquiry
CDCB181101 Rabbit CST3 ORF clone (NM_001082706.1) Inquiry
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