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CRYGA


Official Full Name
crystallin gamma A
Organism
Homo sapiens
Gene ID
1418
Background
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]
Synonyms
CRYG1; CRYG5; CRY-g-A

Cat.No. Product Name Price
SHG201265 shRNA set against Mouse Cryga(NM_007774.3) Inquiry
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SHH270009 shRNA set against Mouse CRYGA (NM_007774.3) Inquiry
Cat.No. Product Name Price
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CDCR050904 Human CRYGA ORF clone (NM_014617.3) Inquiry
CDCR050906 Mouse Cryga ORF clone (NM_007774.3) Inquiry
CDCR372152 Rat Cryga ORF Clone(NM_001080936.1) Inquiry
CDCS413710 Human CRYGA ORF Clone (BC114456) Inquiry
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