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CRYAA


Official Full Name
crystallin alpha A
Organism
Homo sapiens
Gene ID
1409
Background
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]
Synonyms
CRYA1; HSPB4; CTRCT9

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SHG200833 shRNA set against Rat Cryaa(NM_012534.2) Inquiry
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Cat.No. Product Name Price
CDFH004287 Human CRYAA cDNA Clone(NM_000394.2) Inquiry
CDFR010355 Rat Cryaa cDNA Clone(NM_012534.2) Inquiry
MiUTR1H-02443 CRYAA miRNA 3'UTR clone Inquiry
MiUTR1M-03357 CRYAA miRNA 3'UTR clone Inquiry
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CDCB162912 Chicken CRYAA ORF Clone (NM_001030797) Inquiry
CDCB176778 Danio rerio CRYAA ORF Clone (NM_152950) Inquiry
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CDCR050864 Human CRYAA ORF clone (NM_000394.2) Inquiry
CDCR050866 Mouse Cryaa ORF clone (NM_013501.2) Inquiry
CDCR377282 Rat Cryaa ORF Clone(NM_012534.2) Inquiry
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