Pages
Products

CLPB


Official Full Name
ClpB family mitochondrial disaggregase
Organism
Homo sapiens
Gene ID
81570
Background
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Synonyms
SCN9; SKD3; HSP78; MGCA7; ANKCLB; ANKCLP; MGCA7A; MEGCANN

Cat.No. Product Name Price
SHG184051 shRNA set against Rat Clpb(NM_022947.1) Inquiry
SHG183997 shRNA set against Mouse Clpb(NM_009191.3) Inquiry
SHH265577 shRNA set against Human CLPB (NM_030813.4) Inquiry
SHH265581 shRNA set against Mouse CLPB (NM_009191.3) Inquiry
SHH265585 shRNA set against Rat CLPB (NM_022947.1) Inquiry
Cat.No. Product Name Price
CDCR048276 Human CLPB ORF clone (NM_001258393.1) Inquiry
CDCS416019 Human CLPB ORF Clone (BC006257) Inquiry
CDFR012170 Rat Clpb cDNA Clone(NM_022947.1) Inquiry
MiUTR1M-03110 CLPB miRNA 3'UTR clone Inquiry
MiUTR1R-01056 CLPB miRNA 3'UTR clone Inquiry
MiUTR3H-14481 CLPB miRNA 3'UTR clone Inquiry
CDCB160193 Human CLPB ORF clone (BC006404) Inquiry
CDCB192658 Rabbit CLPB ORF clone (XM_002708715.2) Inquiry
CDCR048274 Human CLPB ORF clone (NM_001258392.1) Inquiry
CDCR048278 Human CLPB ORF clone (NM_001258394.1) Inquiry
CDCR048282 Mouse Clpb ORF clone (NM_009191.3) Inquiry
CDCR379217 Rat Clpb ORF Clone(NM_022947.1) Inquiry
CDCS416018 Human CLPB ORF Clone (BC006404) Inquiry
Quick Inquiry