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CIC


Official Full Name
capicua transcriptional repressor
Organism
Homo sapiens
Gene ID
23152
Background
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Synonyms
MRD45

Cat.No. Product Name Price
SHH409388 shRNA set against Rat SLC25A1 (NM_017307.3) Inquiry
SHG169577 shRNA set against Human CIC(NM_015125.3) Inquiry
SHG169595 shRNA set against Mouse Cic(NM_027882.3) Inquiry
SHG169631 shRNA set against Rat Slc25a1(NM_017307.3) Inquiry
SHH264025 shRNA set against Human CIC (NM_015125.3) Inquiry
SHH264029 shRNA set against Mouse CIC (NM_027882.3) Inquiry
SHH264033 shRNA set against Rat CIC (NM_001107490.3) Inquiry
SHH409380 shRNA set against Human SLC25A1 (NM_005984.3) Inquiry
SHH409384 shRNA set against Mouse SLC25A1 (NM_153150.2) Inquiry
SHL002442 shRNA set against Human SLC25A1(NM_005984.3) Inquiry
Cat.No. Product Name Price
CDCB184330 Rabbit CIC ORF clone (XM_008249683.1) Inquiry
MiUTR1R-07417 SLC25A1 miRNA 3'UTR clone Inquiry
MiUTR1M-03045 CIC miRNA 3'UTR clone Inquiry
MiUTR1H-09473 SLC25A1 miRNA 3'UTR clone Inquiry
MiUTR1H-02164 CIC miRNA 3'UTR clone Inquiry
CDFR011354 Rat Slc25a1 cDNA Clone(NM_017307.3) Inquiry
CDFR007183 Rat Cic cDNA Clone(NM_001107490.3) Inquiry
CDFL002735 Mouse Cic cDNA Clone(NM_027882.3) Inquiry
CDFG018956 Mouse Cic cDNA Clone(NM_001110131.1) Inquiry
SKO0220 SLC25A1 Validated sgRNA vector Inquiry
CDFG018955 Mouse Cic cDNA Clone(NM_001110132.1) Inquiry
CDCR374232 Rat Cic ORF Clone(NM_001107490.3) Inquiry
CDCS410084 Human SLC25A1 ORF Clone (BC004980) Inquiry
SKO0255 CIC Validated sgRNA vector Inquiry
CDCR378408 Rat Slc25a1 ORF Clone(NM_017307.3) Inquiry
CDCR047270 Mouse Cic ORF clone (NM_001110132.1) Inquiry
CDCR047268 Mouse Cic ORF clone (NM_027882.3) Inquiry
CDCR047264 Mouse Cic ORF clone (NM_001110131.1) Inquiry
CDCH400742 Mouse SLC25A1 ORF clone(NM_153150.2) Inquiry
CDCH077856 human SLC25A1 ORF clone (NM_001256534.1) Inquiry
CDCB187209 Rabbit SLC25A1 ORF clone (XM_008250237.1) Inquiry
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