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CFI


Official Full Name
complement factor I
Organism
Homo sapiens
Gene ID
3426
Background
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
Synonyms
FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA

Cat.No. Product Name Price
SHG169479 shRNA set against Human CFI(NM_000204.3) Inquiry
SHH262473 shRNA set against Rat CFI (NM_024157.1) Inquiry
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SHH262465 shRNA set against Human CFI (NM_000204.3) Inquiry
SHH262469 shRNA set against Mouse CFI (NM_007686.2) Inquiry
SHW003643 shRNA set against Chicken CFI (NM_001272018) Inquiry
Cat.No. Product Name Price
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MiUTR1M-02969 CFI miRNA 3'UTR clone Inquiry
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CDCB194274 Rabbit CFI ORF clone (XM_002717131.2) Inquiry
CDCR046374 Human CFI ORF clone (NM_000204.3) Inquiry
CDCR046378 Mouse Cfi ORF clone (NM_007686.2) Inquiry
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