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CASP1


Official Full Name
caspase 1
Organism
Homo sapiens
Gene ID
834
Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Synonyms
ICE; P45; IL1BC

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SHG142183 shRNA set against Mouse Casp1(NM_009807.2) Inquiry
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SHH254929 shRNA set against Mouse CASP1 (NM_009807.2) Inquiry
SHH254933 shRNA set against Rat CASP1 (NM_012762.2) Inquiry
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Cat.No. Product Name Price
CDCR247925 Mouse Casp1 ORF Clone(NM_009807.2) Inquiry
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MiUTR1M-02539 CASP1 miRNA 3'UTR clone Inquiry
MiUTR3H-01230 CASP1 miRNA 3'UTR clone Inquiry
MiUTR3H-01231 CASP1 miRNA 3'UTR clone Inquiry
MiUTR3H-01232 CASP1 miRNA 3'UTR clone Inquiry
MiUTR3H-01233 CASP1 miRNA 3'UTR clone Inquiry
MiUTR3H-01234 CASP1 miRNA 3'UTR clone Inquiry
CDCB176415 Danio rerio CASPA ORF Clone (NM_131505) Inquiry
CDCB195446 Rabbit CASP1 ORF clone (XM_008262043.1) Inquiry
CDCR313734 Human CASP1 ORF Clone(NM_033295.3) Inquiry
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