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CTRB1


Official Full Name
chymotrypsinogen B1
Organism
Homo sapiens
Gene ID
1504
Background
This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the CTRB2 gene is diagnostic for this inversion. This CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jan 2021]
Synonyms
CTRB

Cat.No. Product Name Price
SHH271417 shRNA set against Human CTRB1 (NM_001906.4) Inquiry
SHH271421 shRNA set against Mouse CTRB1 (NM_025583.2) Inquiry
SHH271425 shRNA set against Rat CTRB1 (NM_012536.1) Inquiry
SHW017782 shRNA set against Danio rerio CTRB1 (NM_212618) Inquiry
Cat.No. Product Name Price
CDFR010357 Rat Ctrb1 cDNA Clone(NM_012536.1) Inquiry
MiUTR1H-02538 CTRB1 miRNA 3'UTR clone Inquiry
MiUTR1R-01257 CTRB1 miRNA 3'UTR clone Inquiry
CDCB179257 Danio rerio CTRB1 ORF Clone (NM_212618) Inquiry
CDCH384406 Mouse CTRB1 ORF clone(NM_025583.2) Inquiry
CDCR051710 Human CTRB1 ORF clone (NM_001906.4) Inquiry
CDCR377284 Rat Ctrb1 ORF Clone(NM_012536.1) Inquiry
CDCS410510 Human CTRB1 ORF Clone (BC005385) Inquiry
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