Pages
Products

CRYAB


Official Full Name
crystallin alpha B
Organism
Homo sapiens
Gene ID
1410
Background
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]
Synonyms
MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101

Cat.No. Product Name Price
SHG200841 shRNA set against Human CRYAB(NM_001885.1) Inquiry
SHG200971 shRNA set against Mouse Cryab(NM_009964.2) Inquiry
SHG201031 shRNA set against Rat Cryab(NM_012935.3) Inquiry
SHH269909 shRNA set against Human CRYAB (NM_001885.1) Inquiry
SHH269913 shRNA set against Mouse CRYAB (NM_009964.2) Inquiry
SHH269917 shRNA set against Rat CRYAB (NM_012935.3) Inquiry
SHW005674 shRNA set against Chicken CRYAB (NM_205176) Inquiry
Cat.No. Product Name Price
CDCR248182 Mouse Cryab ORF Clone(NM_009964.2) Inquiry
CDFH004288 Human CRYAB cDNA Clone(NM_001885.1) Inquiry
CDFR010633 Rat Cryab cDNA Clone(NM_012935.3) Inquiry
MiUTR1H-02444 CRYAB miRNA 3'UTR clone Inquiry
MiUTR1M-03358 CRYAB miRNA 3'UTR clone Inquiry
MiUTR1R-01198 CRYAB miRNA 3'UTR clone Inquiry
CDCB167149 Chicken CRYAB ORF Clone (NM_205176) Inquiry
CDCB180587 Rabbit CRYAB ORF clone (NM_001082407.1) Inquiry
CDCR050868 Human CRYAB ORF clone (NM_001885.1) Inquiry
CDCR377790 Rat Cryab ORF Clone(NM_012935.3) Inquiry
CDCS410496 Human CRYAB ORF Clone (BC007008) Inquiry
Quick Inquiry