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CR1


Official Full Name
complement C3b/C4b receptor 1 (Knops blood group)
Organism
Homo sapiens
Gene ID
1378
Background
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
Synonyms
KN; C3BR; C4BR; CD35

Cat.No. Product Name Price
SHG197189 shRNA set against Human CR1(NM_000573.3) Inquiry
SHG197215 shRNA set against Human CR1(NM_000651.4) Inquiry
SHG197257 shRNA set against Human CR1(NM_000573.3) Inquiry
SHH269105 shRNA set against Human CR1 (NM_000573.3) Inquiry
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SHH320397 shRNA set against Mouse IQCJ (NM_177585.3) Inquiry
SHH331499 shRNA set against Rat LOC171161 (NM_133622.2) Inquiry
Cat.No. Product Name Price
CDCR337160 Human CR1 ORF Clone(NM_000573.3) Inquiry
MiUTR1H-02403 CR1 miRNA 3'UTR clone Inquiry
MiUTR1H-02404 CR1 miRNA 3'UTR clone Inquiry
MiUTR1M-04199 IQCJ miRNA 3'UTR clone Inquiry
MiUTR3H-12015 IQCJ miRNA 3'UTR clone Inquiry
MiUTR3H-12016 IQCJ miRNA 3'UTR clone Inquiry
CDCB195691 Rabbit LOC100144334 ORF clone (XM_008268652.1) Inquiry
CDCB197413 Rabbit LOC103345959 ORF clone (XM_008251338.1) Inquiry
CDCL121441 Human IQCJ ORF clone (NM_001197100.1) Inquiry
CDCR236921 Mouse Iqcj ORF Clone(NM_001113419.2) Inquiry
CDCR273995 Mouse Iqcj ORF Clone(NM_177585.3) Inquiry
CDCR344722 Human IQCJ ORF Clone(NM_001042705.2) Inquiry
CDCR381185 Rat LOC171161 ORF Clone(NM_133622.2) Inquiry
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