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CPSF4


Official Full Name
cleavage and polyadenylation specific factor 4
Organism
Homo sapiens
Gene ID
10898
Background
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Synonyms
NAR; NEB1; NEB-1; CPSF30

Cat.No. Product Name Price
SHG170803 shRNA set against Human CPSF4(NM_006693.2) Inquiry
SHG170845 shRNA set against Human CPSF4(NM_001081559.1) Inquiry
SHG170917 shRNA set against Mouse Cpsf4(NM_178576.2) Inquiry
SHH268957 shRNA set against Human CPSF4 (NM_006693.2) Inquiry
SHH268961 shRNA set against Mouse CPSF4 (NM_178576.2) Inquiry
SHH268965 shRNA set against Rat CPSF4 (NM_001012351.2) Inquiry
SHW003880 shRNA set against Chicken CPSF4 (NM_001277551) Inquiry
SHW014526 shRNA set against Danio rerio CPSF4 (NM_131009) Inquiry
Cat.No. Product Name Price
CDCR274840 Mouse Cpsf4 ORF Clone(NM_178576.2) Inquiry
CDCS407328 Human CPSF4 ORF Clone (BC003101) Inquiry
CDFH004190 Human CPSF4 cDNA Clone(NM_001081559.1) Inquiry
CDFL003055 Mouse Cpsf4 cDNA Clone(NM_178576.2) Inquiry
MiUTR1H-02399 CPSF4 miRNA 3'UTR clone Inquiry
MiUTR1H-02400 CPSF4 miRNA 3'UTR clone Inquiry
CDCB165355 Chicken CPSF4 ORF Clone (NM_001277551) Inquiry
CDCB176001 Danio rerio CPSF4 ORF Clone (NM_131009) Inquiry
CDCB190164 Rabbit CPSF4 ORF clone (XM_008248918.1) Inquiry
CDCR345992 Human CPSF4 ORF Clone(NM_001081559.1) Inquiry
CDCR369717 Rat Cpsf4 ORF Clone(NM_001012351.2) Inquiry
CDCS407329 Human CPSF4 ORF Clone (BC050738) Inquiry
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