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COX10


Official Full Name
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
Organism
Homo sapiens
Gene ID
1352
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
Synonyms
MC4DN3

Cat.No. Product Name Price
SHH268153 shRNA set against Human COX10 (NM_001303.3) Inquiry
SHG193897 shRNA set against Mouse Cox10(NM_178379.3) Inquiry
SHH268157 shRNA set against Mouse COX10 (NM_178379.3) Inquiry
SHW001345 shRNA set against Chicken COX10 (NM_001030700) Inquiry
SHW013492 shRNA set against Danio rerio COX10 (NM_001166259) Inquiry
Cat.No. Product Name Price
MiUTR1M-03255 COX10 miRNA 3'UTR clone Inquiry
MiUTR3H-04680 COX10 miRNA 3'UTR clone Inquiry
CDCB162820 Chicken COX10 ORF Clone (NM_001030700) Inquiry
CDCB174967 Danio rerio COX10 ORF Clone (NM_001166259) Inquiry
CDCR049812 Human COX10 ORF clone (NM_001303.3) Inquiry
CDCS410218 Human COX10 ORF Clone (BC000060) Inquiry
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