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CLOCK


Official Full Name
clock circadian regulator
Organism
Homo sapiens
Gene ID
9575
Background
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Synonyms
KAT13D; bHLHe8

Cat.No. Product Name Price
SHG183593 shRNA set against Mouse Clock(NM_007715.5) Inquiry
SHG183597 shRNA set against Rat Clock(NM_021856.1) Inquiry
SHH265553 shRNA set against Human CLOCK (NM_004898.3) Inquiry
SHH265561 shRNA set against Rat CLOCK (NM_021856.1) Inquiry
SHW004431 shRNA set against Chicken CLOCK (NM_001289834) Inquiry
SHW004691 shRNA set against Chicken CLOCK (NM_204174) Inquiry
SHW014480 shRNA set against Danio rerio CLOCKA (NM_130957) Inquiry
Cat.No. Product Name Price
CDFG022034 Mouse Clock cDNA Clone(NM_007715.5) Inquiry
CDFR011792 Rat Clock cDNA Clone(NM_021856.1) Inquiry
MiUTR1M-03108 CLOCK miRNA 3'UTR clone Inquiry
MiUTR1R-01054 CLOCK miRNA 3'UTR clone Inquiry
MiUTR4H-TG02188 CLOCK miRNA 3'UTR clone Inquiry
SKO0389 CLOCK Validated sgRNA vector Inquiry
CDCB159522 Human CLOCK ORF clone (BC126157) Inquiry
CDCB165906 Chicken CLOCK ORF Clone (NM_001289834) Inquiry
CDCB166166 Chicken CLOCK ORF Clone (NM_204174) Inquiry
CDCB175955 Danio rerio CLOCKA ORF Clone (NM_130957) Inquiry
CDCB188066 Rabbit CLOCK ORF clone (XM_008267850.1) Inquiry
CDCR048256 Mouse Clock ORF clone (NM_007715.5) Inquiry
CDCR378850 Rat Clock ORF Clone(NM_021856.1) Inquiry
CDCS412010 Human CLOCK ORF Clone (BC126157) Inquiry
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