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CIITA


Official Full Name
class II major histocompatibility complex transactivator
Organism
Homo sapiens
Gene ID
4261
Background
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Synonyms
C2TA; NLRA; MHC2D1; MHC2TA; CIITAIV

Cat.No. Product Name Price
SHH264085 shRNA set against Human CIITA (NM_000246.3) Inquiry
SHH264089 shRNA set against Mouse CIITA (NM_007575.3) Inquiry
SHH264093 shRNA set against Rat CIITA (NM_053529.2) Inquiry
Cat.No. Product Name Price
MiUTR1H-02167 CIITA miRNA 3'UTR clone Inquiry
CDCB194292 Rabbit CIITA ORF clone (XM_008257715.1) Inquiry
CDCR243881 Mouse Ciita ORF Clone(NM_007575.3) Inquiry
CDCR380171 Rat Ciita ORF Clone(NM_053529.2) Inquiry
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