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CEP57


Official Full Name
centrosomal protein 57
Organism
Homo sapiens
Gene ID
9702
Background
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Synonyms
MVA2; PIG8; TSP57

Cat.No. Product Name Price
SHH261933 shRNA set against Human CEP57 (NM_014679.4) Inquiry
SHH261937 shRNA set against Mouse CEP57 (NM_026665.4) Inquiry
SHH261941 shRNA set against Rat CEP57 (NM_001108124.3) Inquiry
SHW011040 shRNA set against Danio rerio CEP57 (NM_001080683) Inquiry
Cat.No. Product Name Price
CDCB158409 Human CEP57 ORF clone (BC039711) Inquiry
MiUTR3H-09601 CEP57 miRNA 3'UTR clone Inquiry
CDCB172515 Danio rerio CEP57 ORF Clone (NM_001080683) Inquiry
CDCB186014 Rabbit CEP57 ORF clone (XM_008262382.1) Inquiry
CDCR046098 Human CEP57 ORF clone (NM_001243776.1) Inquiry
CDCR259081 Mouse Cep57 ORF Clone(NM_026665.4) Inquiry
CDCR374685 Rat Cep57 ORF Clone(NM_001108124.3) Inquiry
CDCS409879 Human CEP57 ORF Clone (BC039711) Inquiry
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