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CCNE1


Official Full Name
cyclin E1
Organism
Homo sapiens
Gene ID
898
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
Synonyms
CCNE; pCCNE1

Cat.No. Product Name Price
SHG152299 shRNA set against Rat Ccne1(NM_001100821.1) Inquiry
SHG152317 shRNA set against Mouse Ccne1(NM_007633.2) Inquiry
SHH257881 shRNA set against Human CCNE1 (NM_001238.2) Inquiry
SHH257889 shRNA set against Rat CCNE1 (NM_001100821.1) Inquiry
SHW001953 shRNA set against Chicken CCNE1 (NM_001031358) Inquiry
SHW014516 shRNA set against Danio rerio CCNE1 (NM_130995) Inquiry
Cat.No. Product Name Price
CDFR005372 Rat Ccne1 cDNA Clone(NM_001100821.1) Inquiry
MiUTR1M-02691 CCNE1 miRNA 3'UTR clone Inquiry
MiUTR1R-00812 CCNE1 miRNA 3'UTR clone Inquiry
MiUTR3H-00584 CCNE1 miRNA 3'UTR clone Inquiry
CDCB163428 Chicken CCNE1 ORF Clone (NM_001031358) Inquiry
CDCB175991 Danio rerio CCNE1 ORF Clone (NM_130995) Inquiry
CDCB195409 Rabbit CCNE1 ORF clone (XM_002721146.2) Inquiry
CDCL183140 Mouse CCNE1 ORF clone(NM_007633.2) Inquiry
CDCR372392 Rat Ccne1 ORF Clone(NM_001100821.1) Inquiry
CDCS409735 Human CCNE1 ORF Clone (BC035498) Inquiry
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