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CCND2


Official Full Name
cyclin D2
Organism
Homo sapiens
Gene ID
894
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Synonyms
MPPH3; KIAK0002

Cat.No. Product Name Price
SHG152173 shRNA set against Mouse Ccnd2(NM_009829.3) Inquiry
SHG152227 shRNA set against Rat Ccnd2(NM_022267.1) Inquiry
SHH257845 shRNA set against Human CCND2 (NM_001759.3) Inquiry
SHH257849 shRNA set against Mouse CCND2 (NM_009829.3) Inquiry
SHH257853 shRNA set against Rat CCND2 (NM_022267.1) Inquiry
SHW004730 shRNA set against Chicken CCND2 (NM_204213) Inquiry
Cat.No. Product Name Price
CDCL183135 Human CCND2 ORF clone(NM_001759.3) Inquiry
CDCL183136 Mouse CCND2 ORF clone(NM_009829.3) Inquiry
CDFR011950 Rat Ccnd2 cDNA Clone(NM_022267.1) Inquiry
MiUTR1M-02686 CCND2 miRNA 3'UTR clone Inquiry
MiUTR1R-00809 CCND2 miRNA 3'UTR clone Inquiry
CDCB166205 Chicken CCND2 ORF Clone (NM_204213) Inquiry
CDCB195531 Rabbit CCND2 ORF clone (XM_002712830.2) Inquiry
CDCR378953 Rat Ccnd2 ORF Clone(NM_022267.1) Inquiry
CDCS410420 Human CCND2 ORF Clone (BC010958) Inquiry
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