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CBL


Official Full Name
Cbl proto-oncogene
Organism
Homo sapiens
Gene ID
867
Background
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Synonyms
CBL2; NSLL; C-CBL; RNF55; FRA11B

Cat.No. Product Name Price
SHH255305 shRNA set against Mouse CBL (NM_007619.2) Inquiry
SHG144367 shRNA set against Mouse Cbl(NM_007619.2) Inquiry
SHH255301 shRNA set against Human CBL (NM_005188.3) Inquiry
SHW004725 shRNA set against Chicken CBL (NM_204208) Inquiry
SHW007606 shRNA set against Danio rerio CBL (NM_001007330) Inquiry
Cat.No. Product Name Price
CDCR041958 Mouse Cbl ORF clone (NM_007619.2) Inquiry
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CDCB160340 Human CBL ORF clone (NM_005188.2) Inquiry
CDCB166200 Chicken CBL ORF Clone (NM_204208) Inquiry
CDCB169081 Danio rerio CBL ORF Clone (NM_001007330) Inquiry
CDCB192139 Rabbit CBL ORF clone (XM_008250509.1) Inquiry
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