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Casc5


Official Full Name
kinetochore scaffold 1
Organism
Mus musculus
Gene ID
76464
Background
Predicted to enable microtubule binding activity. Involved in homologous chromosome orientation in meiotic metaphase I and positive regulation of meiosis I spindle assembly checkpoint. Located in cytoplasm and kinetochore. Is expressed in cerebral cortex ventricular layer; telencephalon; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 4; and sarcoma. Orthologous to human KNL1 (kinetochore scaffold 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Knl1; Casc5; 2310043D08Rik; 5730505K17Rik

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