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CARD8


Official Full Name
caspase recruitment domain family member 8
Organism
Homo sapiens
Gene ID
22900
Background
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Synonyms
NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL

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SHH254725 shRNA set against Human CARD8 (NM_014959.3) Inquiry
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CDCR041466 Human CARD8 ORF clone (NM_001184900.1) Inquiry
CDCR041468 Human CARD8 ORF clone (NM_001184902.1) Inquiry
CDCR041470 Human CARD8 ORF clone (NM_001184901.1) Inquiry
CDCR357652 Human CARD8 ORF Clone(NM_001184903.1) Inquiry
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