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C5orf20

Official Full Name
chromosome 5 open reading frame 20
Background
This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans.
Synonyms
C5ORF20; chromosome 5 open reading frame 20; dendritic cell nuclear protein 1; DCNP1

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