Pages
Products

BPTF


Official Full Name
bromodomain PHD finger transcription factor
Organism
Homo sapiens
Gene ID
2186
Background
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Synonyms
FAC1; FALZ; NEDDFL; NURF301

Cat.No. Product Name Price
SHH247510 shRNA set against Mouse Bptf (NM_176850.2) Inquiry
SHG103753 shRNA set against Mouse Bptf(NM_176850.2) Inquiry
SHG103789 shRNA set against Human BPTF(NM_004459.6) Inquiry
SHG103825 shRNA set against Human BPTF(NM_182641.3) Inquiry
SHH247506 shRNA set against Human Bptf (NM_182641.3) Inquiry
Cat.No. Product Name Price
CDFL001953 Mouse Bptf cDNA Clone(NM_176850.2) Inquiry
MiUTR1H-00935 BPTF miRNA 3'UTR clone Inquiry
MiUTR1H-00936 BPTF miRNA 3'UTR clone Inquiry
MiUTR1M-02254 BPTF miRNA 3'UTR clone Inquiry
CDCB182558 Rabbit BPTF ORF clone (XM_008271728.1) Inquiry
CDCR273363 Mouse Bptf ORF Clone(NM_176850.2) Inquiry
CDCR288066 Human BPTF ORF Clone(NM_004459.6) Inquiry
Quick Inquiry