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BEST1


Official Full Name
bestrophin 1
Organism
Homo sapiens
Gene ID
7439
Background
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
Synonyms
ARB; BMD; BEST; RP50; VMD2; TU15B; Best1V1Delta2

Cat.No. Product Name Price
SHG099405 shRNA set against Mouse Best1(NM_011913.2) Inquiry
SHH246366 shRNA set against Human BEST1 (NM_004183.3) Inquiry
SHH246370 shRNA set against Mouse BEST1 (NM_011913.2) Inquiry
SHH246374 shRNA set against Rat BEST1 (NM_001011940.1) Inquiry
Cat.No. Product Name Price
OE-PNDC000444 Human BEST1 Nanodisc Inquiry
Cat.No. Product Name Price
CDFH001775 Human BEST1 cDNA Clone(NM_001139443.1) Inquiry
CDFR002370 Rat Best1 cDNA Clone(NM_001011940.1) Inquiry
MiUTR1M-02183 BEST1 miRNA 3'UTR clone Inquiry
MiUTR1R-08534 BEST1 miRNA 3'UTR clone Inquiry
MiUTR3H-09509 BEST1 miRNA 3'UTR clone Inquiry
MiUTR3H-09510 BEST1 miRNA 3'UTR clone Inquiry
CDCB186551 Rabbit BEST1 ORF clone (XM_008274403.1) Inquiry
CDCR034414 Human BEST1 ORF clone (NM_001139443.1) Inquiry
CDCR251391 Mouse Best1 ORF Clone(NM_011913.2) Inquiry
CDCR369457 Rat Best1 ORF Clone(NM_001011940.1) Inquiry
CDCS408223 Human BEST1 ORF Clone (BC015220) Inquiry
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