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BCCIP


Official Full Name
BRCA2 and CDKN1A interacting protein
Organism
Homo sapiens
Gene ID
56647
Background
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Synonyms
TOK1; TOK-1

Cat.No. Product Name Price
SHH245774 shRNA set against Human BCCIP (NM_016567.3) Inquiry
SHH245778 shRNA set against Mouse BCCIP (NM_025392.2) Inquiry
SHG096451 shRNA set against Mouse Bccip(NM_025392.2) Inquiry
SHH245782 shRNA set against Rat BCCIP (NM_001108505.2) Inquiry
SHW008042 shRNA set against Danio rerio BCCIP (NM_001013475) Inquiry
Cat.No. Product Name Price
MiUTR1M-02146 BCCIP miRNA 3'UTR clone Inquiry
MiUTR3H-12196 BCCIP miRNA 3'UTR clone Inquiry
MiUTR3H-12197 BCCIP miRNA 3'UTR clone Inquiry
MiUTR3H-12198 BCCIP miRNA 3'UTR clone Inquiry
CDCB158934 Human BCCIP ORF clone (BC009771) Inquiry
CDCB169517 Danio rerio BCCIP ORF Clone (NM_001013475) Inquiry
CDCB192824 Rabbit BCCIP ORF clone (XM_008274830.1) Inquiry
CDCR034016 Human BCCIP ORF clone (NM_078469.2) Inquiry
CDCR034018 Human BCCIP ORF clone (NM_078468.2) Inquiry
CDCR256883 Mouse Bccip ORF Clone(NM_025392.2) Inquiry
CDCR374998 Rat Bccip ORF Clone(NM_001108505.2) Inquiry
CDCS414337 Human BCCIP ORF Clone (BC009771) Inquiry
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