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BAMBI

Official Full Name
BMP and activin membrane-bound inhibitor
Background
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.
Synonyms
BAMBI; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); BMP and activin membrane-bound inhibitor homolog; NMA; BAMBI_HUMAN; BMP and activin membrane bound inhibitor homolog; Non metastatic gene A protein; Non-metastatic gene A protein; Putative transmembrane protein NMA; OTTHUMP00000019384

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