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ATP6AP1

Official Full Name
ATPase H+ transporting accessory protein 1
Organism
Homo sapiens
GeneID
537
Background
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
Synonyms
16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1;

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