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ARHGEF26

Official Full Name
Rho guanine nucleotide exchange factor 26
Organism
Homo sapiens
GeneID
26084
Background
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Synonyms
SGEF; CSGEF; HMFN1864;

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