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APOB


Official Full Name
apolipoprotein B
Organism
Homo sapiens
Gene ID
338
Background
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL), and is the ligand for the LDL receptor. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Dec 2019]
Synonyms
FLDB; FCHL2; LDLCQ4; apoB-48; apoB-100

Cat.No. Product Name Price
LV05216L human APOB (NM_000384) lentivirus particles Inquiry
Cat.No. Product Name Price
SHH238386 shRNA set against Rat APOB (NM_019287.2) Inquiry
SHG065125 shRNA set against Mouse Apob(NM_009693.2) Inquiry
SHG065161 shRNA set against Human APOB(NM_000384.2) Inquiry
SHG065179 shRNA set against Rat Apob(NM_019287.2) Inquiry
SHH238378 shRNA set against Human APOB (NM_000384.2) Inquiry
SHH238382 shRNA set against Mouse APOB (NM_009693.2) Inquiry
SHW002367 shRNA set against Chicken APOB (NM_001044633) Inquiry
Cat.No. Product Name Price
CDFR011379 Rat Apob cDNA Clone(NM_019287.2) Inquiry
MiUTR1H-00471 APOB miRNA 3'UTR clone Inquiry
MiUTR1M-01579 APOB miRNA 3'UTR clone Inquiry
MiUTR1R-00307 APOB miRNA 3'UTR clone Inquiry
CDCB163842 Chicken APOB ORF Clone (NM_001044633) Inquiry
CDCB180866 Rabbit APOB ORF clone (XM_008254783.1) Inquiry
CDCH015969 Mouse APOB ORF clone(NM_009693.2) Inquiry
CDCR378581 Rat Apob ORF Clone(NM_019287.2) Inquiry
Cat.No. Product Name Price
CC-145 APOB Easy KO Kit Inquiry
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