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AFF1


Official Full Name
ALF transcription elongation factor 1
Organism
Homo sapiens
Gene ID
4299
Background
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Synonyms
AF4; FEL; PBM1; MLLT2

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Cat.No. Product Name Price
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CDFR006931 Rat Aff1 cDNA Clone(NM_001107206.1) Inquiry
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CDCR025354 Mouse Aff1 ORF clone (NM_133919.3) Inquiry
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