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Adipoq

Official Full Name
adiponectin, C1Q and collagen domain containing
Background
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Synonyms
ADIPOQ; adiponectin, C1Q and collagen domain containing; APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30; adiponectin; adipocyte-specific protein AdipoQ; adipocyte complement related protein; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; ACDC, adipocyte, C1Q and collagen domain containing; adipose most abundant gene transcript 1; gelatin-binding protein 28; adipose specific collagen-like factor; adipose most abundant gene transcript 1 protein; ADPN; APM-1; ADIPQTL1

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