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ADD2


Official Full Name
adducin 2
Organism
Homo sapiens
Gene ID
119
Background
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

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SHG042067 shRNA set against Rat Add2(NM_012491.2) Inquiry
SHG042127 shRNA set against Mouse Add2(NM_013458.4) Inquiry
SHH232314 shRNA set against Human ADD2 (NM_017482.3) Inquiry
SHH232318 shRNA set against Mouse ADD2 (NM_013458.4) Inquiry
SHH232322 shRNA set against Rat ADD2 (NM_012491.2) Inquiry
Cat.No. Product Name Price
CDFH000367 Human ADD2 cDNA Clone(NM_001185054.1) Inquiry
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MiUTR1R-00138 ADD2 miRNA 3'UTR clone Inquiry
MiUTR1M-01236 ADD2 miRNA 3'UTR clone Inquiry
CDFR010169 Rat Add2 cDNA Clone(NM_012491.2) Inquiry
CDFR009202 Rat Add2 cDNA Clone(NM_001109880.1) Inquiry
CDFL000973 Mouse Add2 cDNA Clone(NM_013458.4) Inquiry
CDFH000368 Human ADD2 cDNA Clone(NM_001185055.1) Inquiry
MiUTR3H-00057 ADD2 miRNA 3'UTR clone Inquiry
MiUTR3H-00056 ADD2 miRNA 3'UTR clone Inquiry
CDCS409173 Human ADD2 ORF Clone (BC041666) Inquiry
CDCR377400 Rat Add2 ORF Clone(NM_012491.2) Inquiry
CDCR376249 Rat Add2 ORF Clone(NM_001109880.1) Inquiry
CDCR357762 Human ADD2 ORF Clone(NM_001185054.1) Inquiry
CDCR251828 Mouse Add2 ORF Clone(NM_013458.4) Inquiry
CDCR024962 Human ADD2 ORF clone (NM_001185055.1) Inquiry
CDCB188466 Rabbit ADD2 ORF clone (XM_008254276.1) Inquiry
CDCB160438 Human ADD2 ORF clone (BC065525.1) Inquiry
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