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ARFGEF1

Official Full Name
ARF guanine nucleotide exchange factor 1
Organism
Homo sapiens
GeneID
10565
Background
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Synonyms
BIG1; P200; DEDISB; ARFGEP1;

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