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APLF

Official Full Name
aprataxin and PNKP like factor
Organism
Homo sapiens
GeneID
200558
Background
Enables several functions, including ADP-D-ribose modification-dependent protein binding activity; nuclease activity; and poly-ADP-D-ribose binding activity. Involved in DNA repair; DNA repair-dependent chromatin remodeling; and protein localization to chromatin. Acts upstream of or within positive regulation of DNA ligation. Located in nucleoplasm. Is active in site of double-strand break. [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
APFL; PALF; Xip1; ZCCHH1; C2orf13;

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