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ALG12

Official Full Name
ALG12 alpha-1,6-mannosyltransferase
Organism
Homo sapiens
GeneID
79087
Background
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008]
Synonyms
CDG1G; ECM39; hALG12; PP14673;

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