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AFF3

Official Full Name
AF4/FMR2 family, member 3
Background
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Synonyms
AFF3; AF4/FMR2 family, member 3; LAF4, lymphoid nuclear protein related to AF4; AF4/FMR2 family member 3; MLLT2 like; protein LAF-4; MLLT2-related protein; lymphoid nuclear protein 4; lymphoid nuclear protein related to AF4; LAF4; MLLT2-like

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