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76P


Official Full Name
tubulin gamma complex component 4
Organism
Homo sapiens
Gene ID
27229
Background
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Synonyms
ARB1; ARR1

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Cat.No. Product Name Price
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CDCB174545 Danio rerio TUBGCP4 ORF Clone (NM_001135130) Inquiry
CDCH074810 human TUBGCP4 ORF clone (NM_014444.2) Inquiry
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