Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
TLR4; toll-like receptor 4; Lps; Ly87; Ran/M1; Rasl2-8; lipopolysaccharide response; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10; TOLL, CD284, hToll, ARMD10