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slc30a8

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Official Full Name
solute carrier family 30 (zinc transporter), member 8
Background
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
SLC30A8; solute carrier family 30 (zinc transporter), member 8; zinc transporter 8; Solute carrier family 30 member 8; zinc transporter ZnT-8; ZnT-8; ZNT8; ZNT8_HUMAN