CD150, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells.
SLAMF1; signaling lymphocytic activation molecule family member 1; signaling lymphocytic activation molecule; signaling lymphocyte activation molecule; Slam; CD150; IPO-3; CDw150; ESTM51; AA177906; 4933415F16; MGC151472; MGC151476; signaling lymphocytic activation molecule , SLAM